Method Development and Validation of a Sensitive and Robust Human Serum PK Immunoassay for a Novel Bispecific Antibody by an Automated Microfluidic System

AAPS ePoster Library, Yan Mao, 393430

Ciprofloxacin-Loaded Albumin Nanoparticles as a New Strategy for the Treatment of Urinary Tract Infections and Catheter-Associated Urinary Tract Infections

AAPS ePoster Library, Javier Morales, 403075

Formulation Development and Characterization of Parenteral Nicardipine HCl Product for Intrathecal Administration

AAPS ePoster Library, Arun Kumar Kotha, 403074

Characterization and Performance of 60% Drug Loaded Freeze-Dried Amorphous Nanoparticle Tablet of a BCS IV Compound: ABT-530

AAPS ePoster Library, Nasim Ganji, 403073

Disruption of Octreotide Interactions with the Bile Acid-Phospholipid Mixed Micelles Using Bile Acid Sequestrants

AAPS ePoster Library, Zahraa Al-Tamimi, 403072

Cellular Uptake and Real-Time ROS Sensing of Doxorubicin-Loaded Self-Assembled Albumin Nanoparticles Using Liver Bilayer Microfluidic Chip System

AAPS ePoster Library, Beom-Jin Lee, 403071

Detecting Low-Level Crystallinity in ASD-Like Samples Using SSNMR Techniques

AAPS ePoster Library, Brian Van Dyke, 403070

Predicting Granule and Tablet Properties Using In-Line Measurements and Evolutionary Equation Discovery

AAPS ePoster Library, Issa Munu, 403069

Advantage and Challenges of PROTAC Research, Development and Manufacturing

AAPS ePoster Library, Liu Liu, 403068

Artificial Intelligence Based Particle Characterization for Predictive Insight of Drug Product Quality and Performance

AAPS ePoster Library, Jeffrey Hall, 403067

Photo-Stability of Peptides Exposed to LED, Fluorescent or UV Light in Liquid and Solid Formulations

AAPS ePoster Library, Natalia Subelzu, 403066

A Workflow for Purity Determination, Intact Mass Measurement, and MS/MS Sequencing of Oligonucleotide Impurities Detected in Synthetic Oligonucleotides

AAPS ePoster Library, Suraj Dhungana, 403065

Trace Level Quantification of Nitrosamine Impurities in Tuberculosis Medicines by LC-MS/MS

AAPS ePoster Library, Qiyao Li, 403064

Concurrent Regulation of OATP1B1 Transport Function by Protein Phosphorylation and Acetylation: Novel Mechanism Underlying Reduced Function of OATP1B1 c.521T >C Single Nucleotide Polymorphism

AAPS ePoster Library, Vishakha Tambe, 403063

Using a Semi-Mechanistic Model to Predict Efficacious Dosing Regimens and Optimal Drug Design Properties for a LNP-Delivered mRNA UGT1A1 Replacement Therapy in Crigler-Najjar Syndrome Type 1 Patients

AAPS ePoster Library, Jamie Nosbisch, 403062

Impact of Pre-incubation on BCRP and P-gp Transporter Inhibition in the Membrane Vesicle Assay

AAPS ePoster Library, Sarah Lazzaro, 403061

Application of Quantitative Models to Systematically Evaluate Factors Impacting Swallowability of Tablets

AAPS ePoster Library, Di Cui, 403060

AI and Experimental-Based Discovery and Preclinical IND-Enabling Studies of Selective BMX Inhibitors for Development of Cancer Therapeutics

AAPS ePoster Library, Ahmed Abu Fayyad, 403059

Should Amorphous Dispersions Always Be Used as a Formulation Development Strategy?

AAPS ePoster Library, Sanjeev Sood, 403058

Drug Product Attributes as an Effect of Formulation Composition of Vardenafil HCl Tablets Produced by the Mixture of the Coprocessed Excipient versus a Similar Spray-Dried Lactose Blend

AAPS ePoster Library, Santhosh Punnoose, 403057

Preparation of Osmotic Tablets Using a Direct-to-Hopper Formulated Push Layer Based on Polyethylene Oxide

AAPS ePoster Library, Lawrence Martin, 403056

Formulation of an Inhalable Nanoemulsion Prepared with a Deep Eutectic Solvent of Pirfenidone and Citric Acid

AAPS ePoster Library, Sumin Ji, 403055

Strategies for Producing Clinical and Commercial RNA-LNP Drug Products

AAPS ePoster Library, Samuel Clarke, 403054

Systemic Delivery of Paclitaxel by Find-Me Nanoparticles Activates Anti-tumor Immunity and Eliminates Tumors

AAPS ePoster Library, Hassan Tammam, 403053

Fabrication of Eco-Benign Isoniazid-Loaded-Silver Nanoparticles: A Novel Approach against Multidrug-Resistant Tuberculosis

AAPS ePoster Library, Tamara Akpobolokemi, 403052

Topical Ocular Administration of Hydrogen Sulfide Donor: Assessment of Permeability through Isolated Bovine Cornea Ex Vivo

AAPS ePoster Library, Anjali Rai, 393455

Rational Development of Fingolimod-Curcumin Nanosuspension as a Potential Intranasal Neuroprotective Therapy after Ischemic Stroke

AAPS ePoster Library, XINYUE ZHANG, 393454

Mass Transport Analysis of Solute Transport through Lipophilic Membranes

AAPS ePoster Library, Na Li, 393453

Impact of Clean Label Lubricant Inclusion Level and Mixing Time on Tablet Properties

AAPS ePoster Library, Ankitkumar Soni, 393452

Encapsulation of Zidovudine via Spray-Drying for Taste-Masking for Incorporation into an Orally Dispersible Film

AAPS ePoster Library, Mikayla Smith, 393451

Design and Development of Nanoformulation of GMC1, a Novel Agent for the Treatment of Castration Resistant Prostate Cancer

AAPS ePoster Library, Mahua Sarkar, 393450

A Nature Inspired Octopus-Shaped 3D Printed Floating Drug Delivery System

AAPS ePoster Library, Vishvesh Raje, 393449

Population Pharmacokinetics of Enrofloxacin and Florfenicol in the Giant Danio (Devario aequipinnatus) following Oral and Bath Administration

AAPS ePoster Library, Jieqiang Zhou, 393448

Ultrasmall Nanoprobes for Fluorescence-Guided Surgical Resection of Peritoneally Disseminated Tumors

AAPS ePoster Library, Neetu Singh, 393447

Mechanistic Analysis of Excessive Viscosity Increase of Drug Nanosuspension during Wet Milling

AAPS ePoster Library, Hiromitsu Ito, 393413

Screening of Synergistic Combination of Ferroptosis-Inducing Drugs and Development of Targeted PLGA Nanoparticles for Improved Anti-Cancer Therapy

AAPS ePoster Library, Sanyog Jain, 393414

Does Elastomer QbD Approach Benefit the E&L Risk Profile for Drug Compatibility? A Comparative Leachables Simulation Study at 12M for Stoppers

AAPS ePoster Library, Todd Jasinski, 393415

A Quality-by-Design Approach for the Development of Inhalable Dry Powder Containing Dual Drug-Loaded Polymeric Nanoparticles for Pulmonary Tuberculosis Treatment

AAPS ePoster Library, Suyash Patil, 393416

Comparison of Controlled-Release Performance between Carrageenan and Several Other Hydrophilic Polymers

AAPS ePoster Library, Zahra Mahmoudi, 393417

Effect of Homotypic vs Heterotypic Interactions on the Cellular Uptake of Extracellular Vesicles

AAPS ePoster Library, Jhanvi Rajan Jhaveri, 393418

Management of Type-2 Diabetes via Exploration of Transdermal Delivery Strategies for Linagliptin

AAPS ePoster Library, Tanvi Karve, 393420

Preparation and Evaluation of Co-Amorphous Formulations of Telmisartan - Amino Acids as a Potential Method for Solubility and Dissolution Enhancement

AAPS ePoster Library, Mai Khanfar, 393421

The Influence of Coating Parameters on Transparency of Semi-permeable Membrane Coating of Push-Pull Osmotic Pump Tablets

AAPS ePoster Library, Shahrzad Missaghi, 393422

Effect of Lung Cancer Exosomal Galectin-3 Binding Protein on Bone Metastasis

AAPS ePoster Library, Pratyusha Ghanta, 393423

Molecular Mechanisms Driving Sex-Dependent Cerebrovascular Inflammation in Alzheimer's disease

AAPS ePoster Library, Vrishali Salian, 393424

A Novel Electrospinning System to Fabricate Bi-axial Nanofibers for Developing a Floating Pharmaceutical Dosage Form

AAPS ePoster Library, Alaa Darwesh, 393425

Biopharmaceutical Analysis of Synthesized Antibiotic Ester Prodrugs; Ciprofloxacin Isopentanoate, Ciprofloxacin N-Butanoate and Ciprofloxacin Isobutanoate

AAPS ePoster Library, Patricia Achi, 393426

Flow Cytometry and Confocal Microscopy to Quantify β-lactam Penetration in a Double β-lactamase and Double Efflux Pump Knockout Strain of Acinetobacter baumannii (AB)

AAPS ePoster Library, Carolin Werkman, 393427

Tangerine-Peel-Derived Nanovesicles Alleviate Hepatic Steatosis in Type 2 Diabetic Mice via Regulating Lipid Metabolism and Intestinal Flora Disorder

AAPS ePoster Library, Junjv Zou, 393428

Impact of In-utero Electronic Cigarette Exposure on Neonatal Neuroimmune and Mitochondrial Function

AAPS ePoster Library, David Mara, 393429

Impact of Extra Components Added to an All-in-One Coprocessed Excipient to Obtain a Better Processability of Cohesive and Poor Flowing Hydrochlorothiazide

AAPS ePoster Library, David Rodriguez, 403076

Development of a Sensitive and Specific Phospho-Tau 217 [Tau (pT217)] Biomarker Assay for Alzheimer’s Disease in Plasma and Serum

AAPS ePoster Library, Seth Harkins, 393431

Evaluation of Free vs Total Measurement of Monoclonal Antibody-Based Therapeutics with Low Binding Affinity to Soluble Target

AAPS ePoster Library, Xinran Liu, 393432

Cetuximab-Based Proteolysis Targeting Chimera for Effectual Downregulation of NSCLC with Varied EGFR Mutations

AAPS ePoster Library, Richa Vartak, 393434

Physical Evaluation of a Late Appearing Polymorph of Ritonavir Form III

AAPS ePoster Library, Susan Bogdanowich-Knipp, 393435

Elucidating the Effect of Processing Temperature and Acid Hydrolysis on Molecular Weight Distribution of Carrageenan

AAPS ePoster Library, Soo Ah Jin, 393437

Quality Assessment of Polysorbates 80 and 20 Pharmaceutical Raw Materials by Measuring Fatty Acids Composition using HPLC with Mass Detection

AAPS ePoster Library, Margaret Maziarz, 393438

An Investigation of Robust Sample Preparation on an Automated Tablet Processing Workstation, and Lessons Learned

AAPS ePoster Library, Ujala Patel, 393439

Optimizing Medication Regimens with Robo-Pharmacist: A Cost-Effective Approach to Reduce Polypharmacy and Improve Adherence

AAPS ePoster Library, Erik Sonntag, 393440

Characterization of Preclinical In Vitro and In Vivo Pharmacokinetics Properties for JNJ-64619178, a New Therapeutic for the Treatment of Medulloblastoma

AAPS ePoster Library, Nusrat Ahmed, 393442

PBPK Modeling Coupled with Biorelevant Dissolution to Forecast the Oral Performance of Amorphous Solid Dispersion Formulations

AAPS ePoster Library, Nitin Charbe, 393443

Pharmacokinetic Characterization of a Novel COVID-19 Inhibitor OJT010 in a Rat Model

AAPS ePoster Library, CBrionne Hendrix, 393444

Assessment of the Effect of Resmetirom, a Liver-Directed, Orally Active, Selective Thyroid Hormone Receptor-β Agonist, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Subjects

AAPS ePoster Library, Ahmed Kousba, 393445

Rivaroxaban Pharmacokinetics after Single Oral Dose in Obese Subjects: An Open-Label Controlled Clinical Trial

AAPS ePoster Library, Ousama Rachid, 393446

Radiation-Induced Tumor Penetration of Mesoporous Silica Nanoparticles for Enhanced Treatment of Ovarian Cancer Peritoneal Metastasis

AAPS ePoster Library, Sheyda Ranjbar, 393408

Manufacturing of Medicated Contact Lenses Using Inkjet Printing

AAPS ePoster Library, Iria Seoane-Viano, 393407

Hydroxypropyl-β-cyclodextrin (HPBCD) in Insoluble Drug-Loaded Nanoparticles Dissolution Studying: A New Approach to Overcoming Sink Limitations

AAPS ePoster Library, Yihan Wang, 393406

Effect of Tetanus Toxoid Fragment C (TTc) and Transferrin (Tf) Functionalized Liposomal Nanoparticle Encapsulating Plasmid APOE2 for the Treatment of Alzheimer’s Disease

AAPS ePoster Library, Jagdish Singh, 393405

A Kupffer Cell-Targeting Nanoparticle System to Mitigate Alcohol-Related Liver Disease (ALD)

AAPS ePoster Library, Janitha Unagolla, 393404

A DoE Approach to Study the Influence of TSWG Process Parameters on the Characteristics of Granules and Tablets

AAPS ePoster Library, Piero Piccinni, 393403

Influence of Bovine Serum Albumin on Colonic Mucus Permeation and Solubility of Celecoxib and Naproxen in Fasted State Simulated Colonic Fluids

AAPS ePoster Library, Denny Suljovic, 393402

Model Based Analysis for Determining Bioequivalence of Metronidazole Topical Cream

AAPS ePoster Library, Seeprarani Rath, 393401

Pharmacokinetics of Mitragynine, a Kratom Alkaloid, in Pregnant Rats: Implications for Maternal and Fetal Health

AAPS ePoster Library, Michelle Kuntz, 393400

Synergistic Chemotherapy for Prostate Cancer Mediated by Brusatol and Docetaxel-Loaded Nanoparticles: Cell Cycle Arrest and Apoptosis Mechanisms

AAPS ePoster Library, Simeon Adesina, 403020

Enteric Functional Ready-to-Fill Capsule Solution from Pre-Clinic to Commercial

AAPS ePoster Library, Mohammed Syed, 403021

A Next Generation Mathematical Model for the In Vitro to Clinical Translation of T-Cell Engagers

AAPS ePoster Library, Fei Hua, 393399

Effect of Amounts of DMSO and Incubation Time on BBB-PAMPA Permeability of Drugs with High and Low BBB Permeability

AAPS ePoster Library, Sehyeok Cheon, 393398

Effects of SDS Quality and Dissolution Medium Warm-Up Time on Dissolution Release of MRTX849 IR Tablets, 200 mg

AAPS ePoster Library, Ken Yu, 393396

Mitigation Strategies to Reduce the Risk of the N-nitrosamine Impurity in Drug Products

AAPS ePoster Library, Diaa Shakleya, 393395

Investigation of Non-specific Adsorption of Lipid Components of the Emulsion-Based Formulations Stored in Glass Vials

AAPS ePoster Library, Erika Patel, 393394

Enabling Formulation Development of LAIs Thorough Understanding Critical Formulation Parameters

AAPS ePoster Library, Nilesh Malavia, 393393

Comparative Study of Suitability for Wet Continuous Production Process Using MCC with Different Characteristics

AAPS ePoster Library, Masaharu Higuchi, 393392

A Multicomponent Media Analysis Workflow using Triple Quadrupole Mass Spectrometry during Human Primary T cell Culture

AAPS ePoster Library, Brian Domanski, 393391

Identifying and Characterizing the Effect of Critical Processing Parameters in Double Emulsion Poly(lactic-co-glycolic) Acid Microparticle Fabrication

AAPS ePoster Library, Elizabeth Bentley, 393390

Could the Plasmatic miRNAs hsa-miR-4433b-5p, hsa-miR-320b and hsa-miR-16-2-2p Be Biomarkers of Covid-19?

AAPS ePoster Library, Eder Pincinato, 393389

Collagen Droplet-Based Micro-Bioreactors for High-Throughput Drug Screening

AAPS ePoster Library, Samantha Ali, 393385

Gut Microbial Metabolites Effect Intracellular Accumulation of Alzheimer’s disease Amyloid Beta Peptides at the Blood-Brain Barrier Endothelium

AAPS ePoster Library, Vaishnavi Veerareddy, 393384

Mitochondrial Activity and Function are Modulated by KLF2 in Rheumatoid Arthritis

AAPS ePoster Library, Md Sariful Islam Howlader, 393383

The Effect of the Edge Activator Combinations in Transethosomal Formulations for Skin Delivery of Thymoquinone

AAPS ePoster Library, Hana Mohd, 393382

Machine Learning Predicts Pharmaceutical Inkjet Printing Outcomes

AAPS ePoster Library, Jun Jie Ong, 393380

Extended Release Abuse Deterrent Formulation of an Opioid Analgesic

AAPS ePoster Library, Girish Nihalani, 393379

Effect of Binary vs Ternary Systems on Stability and Drug Release Performance of Amorphous Solid Dispersions

AAPS ePoster Library, Gaurang Patel, 393378

Combining the Dynamic Gastric Model (DGM) with the Biorelevant Gastrointestinal Transfer (BioGIT) System to Evaluate the Performance of Three Nurofen® Ibuprofen Products

AAPS ePoster Library, Jacob Rune Jørgensen, 393377

The Development and Characterization of Nanocrystal-Loaded Dissolving Microarray Patches for Transdermal Atorvastatin Delivery

AAPS ePoster Library, Yara Naser, 393376

Map the Formulation Space of Lipid Nanoparticles (LNPs) Using Microfluidic Assembly in the Intraperitoneal (IP) Administration of RNA Therapeutics

AAPS ePoster Library, Farhana Islam, 393375

Formulation and In Vitro Anticancer Activity of Folate Receptor Targeted PLGA Nanoparticles Loaded with Apigenin

AAPS ePoster Library, Muhammad Hussain, 393374

Toward Enhanced Stability of mRNA Lipid Nanoparticles

AAPS ePoster Library, Khaled Galal, 393373

A Clinical Study to Assess the Bioequivalence of Topical Diclofenac Products Using Dermal Open Flow Microperfusion

AAPS ePoster Library, Thomas Birngruber, 393371

Development of Therapeutic Immunoliposome to Deliver Recombinant Human Enzyme for the Treatment of Pompe Disease

AAPS ePoster Library, M. Vitoria Bentley, 393370

Repurposing Neratinib for the Treatment of Triple-Negative Breast Cancer by Nanocrystals Formulation Approach

AAPS ePoster Library, Satish Agrawal, 393369